A highly innovative dual-phase treatment leveraging on-demand activation to preserve sensitive actives and maximise their functional performance.

Jourdenwell ExoVesicle 2 Lyophilized Renew Kit is presented in a protective and hermetically sealed amber glass packaging designed to safeguard the stability of delicate ingredients. The separation between the lyophilised phase and the activating liquid ensures both integrity and precision.

In its initial state, the lyophilised component appears as a structured, solid matrix, which upon activation transforms into a clear, fluid solution with a homogeneous appearance, indicative of a well-controlled reconstitution process.

On the nose, the profile remains restrained and unobtrusive, in line with a formulation focused on performance and technological.

Texture-wise, once activated, the product develops into a lightweight fluid that spreads well and is rapidly absorbed. It provides an immediate sensation of hydration, accompanied by a slight and temporary film-forming effect that remains well balanced.

In terms of performance, the product is built around an advanced formulation strategy combining a bi-component system with 3D lyophilisation technology (‘Lyocrystal Structure’). This approach enables the stabilisation and encapsulation of highly sensitive actives, including extracellular vesicles, within a protective matrix, allowing rapid recovery of their functional activity once reconstituted. The inclusion of plant- and microorganism-derived nanovesicles reflects a sophisticated biotech approach targeting key biological pathways such as skin repair, inflammation regulation, collagen synthesis and barrier function.

Key ingredients include:

• Niacinamide (4%), analytically confirmed, contributing to skin balance and overall performance
• Palmitoyl Tripeptide-5, a biomimetic peptide associated with collagen support
• Hyaluronic acid, supporting hydration and moisture retention
• Hydrolysed collagen, contributing to skin elasticity and structure
• Exovesicles (extracellular nanovesicles), targeting repair, inflammation and barrier mechanisms

These ingredients act through complementary pathways, supporting collagen stimulation, improved hydration, strengthened barrier function and modulation of inflammatory mediators.

The product’s performance is supported by data obtained on the finished product, demonstrating a measurable reduction in inflammatory markers (including TNF-α) alongside enhanced skin repair, with results indicating up to a 56% improvement within 24 hours in an in vitro model.

The formulation approach shows strong internal consistency, particularly through the clear separation of phases: sensitive actives are maintained within the lyophilised matrix, while the liquid phase delivers functional components at the point of use, ensuring optimal stability and efficacy. The concentration levels of key ingredients are appropriately calibrated, with niacinamide at 4% and coherent inclusion levels for peptides, hyaluronic acid and exovesicles, all associated with demonstrated biological activity. The preservation strategy relies on multifunctional antimicrobial boosters rather than conventional preservatives and is supported by compliant microbiological validation.

Its combination of advanced delivery technology, coherent formulation strategy and distinctive application ritual supports its recognition as a noteworthy contender for the 2026 Jury Prize.